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YHO-13351 free base

CAS No. 912288-64-3

YHO-13351 free base( YHO13351 free base | YHO 13351 free base )

Catalog No. M16546 CAS No. 912288-64-3

YHO-13351 is an orally available prodrug of YHO-13177, which can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    YHO-13351 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    YHO-13351 is an orally available prodrug of YHO-13177, which can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo.
  • Description
    YHO-13351 is an orally available prodrug of YHO-13177, which can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo; YHO-13351 is rapidly converted into YHO-13177 after its oral or intravenous administration, significantly increases the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model coadministration of irinotecan.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    YHO13351 free base | YHO 13351 free base
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    BCRP
  • Recptor
    BCRP
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    912288-64-3
  • Formula Weight
    483.6229
  • Molecular Formula
    C26H33N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    CCN(CC)CC(=O)OC1CCN(CC1)C2=CC=C(S2)C=C(C#N)C3=CC(=C(C=C3)OC)OC
  • Chemical Name
    Glycine, N,N-diethyl-, 1-[5-[(1Z)-2-cyano-2-(3,4-dimethoxyphenyl)ethenyl]-2-thienyl]-4-piperidinyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yamazaki R, et al. Mol Cancer Ther. 2011 Jul;10(7):1252-63.
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